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KMID : 1007320100160020086
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Journal of the Korean Society of Menopause
2010 Volume.16 No. 2 p.86 ~ p.92
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Comparison of Factors Which Influence the Brachial-Ankle Pulse Wave Velocity in Pre- and Postmenopausal Women
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Chung Chan-Kyung
Yun Bo-Hyon
Seo Seok-Kyo
Lim Kyung-Jin
Jeon Young-Eun
Yang Hyo-In
Lee Kyung-Eun
Cho Si-Hyun
Choi Young-Sik
Lee Byung-Seok
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Abstract
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Objectives: The aim of this study was to compare the factors which influence the brachial-ankle pulse wave velocity (baPWV) in pre- and post-menopausal women. We also investigated the association of menopause with arterial stiffness measured by baPWV.
Methods: We performed a retrospective review of 241 postmenopausal women who attended the health promotion center for a routine checkup. Simple and multiple regression analyses were performed to determine the parameters influencing baPWV in pre- and postmenopausal women. Multiple logistic regression analysis was performed to identify the independent parameters related to increased of arterial stiffness.
Results: Multiple regression analysis showed that diastolic blood pressure (DBP; ? = 0.402, P = 0.009) was identified as an independent determinant for baPWV in premenopausal women, and DBP (? = 0.329, P = 0.021) and the neutrophil-to-lymphocyte ratio (NLR; ? = 0.210, P = 0.016) were identified as independent determinants for baPWV in postmenopausal women. The odds ratio (95% CI) of menopause for a high baPWV was 2.666 (1.025∼6.937).
Conclusion: The NLR is associated with arterial stiffness in postmenopausal women. Consequently, inflammation is thought to play a crucial role in increased arterial stiffness in postmenopausal women. Menopause is associated with a high baPWV, suggesting that changes in the concentrations of sex hormones during the menopausal transition may influence arterial stiffness in clinically healthy women.
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KEYWORD
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Arterial stiffness, Brachial-ankle pulse wave velocity, Premenopausal women, Postmenopausal women
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